The Axon's Balancing Act: cis- and trans-Interactions between Ephs and Ephrins
نویسندگان
چکیده
Ephrin ligands are known to be coexpressed with Eph receptors in certain populations of axons. In this issue of Neuron, Kao and Kania demonstrate the importance of ephrin/Eph cis-interaction for correct pathway selection by spinal motor axons in vivo.
منابع مشابه
Axon Guidance: Opposing EPHects in the Growth Cone
Cells communicate with other cells via (trans) interaction between membrane-linked ephrins and Eph receptors. In this issue of Cell, Pfaff and colleagues (Marquardt et al., 2005) demonstrate that coexpressed ephrin-As and Ephs do not interact in cis but rather segregate into separate membrane domains, from which they signal opposing effects during motor axon guidance.
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عنوان ژورنال:
- Neuron
دوره 71 شماره
صفحات -
تاریخ انتشار 2011